Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication.

Host factors associated with the Sindbis virus RNA - dependent RNA polymerase : 1 a role for G 3 BP 1 and G 3 BP 2 in virus replication

Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: 1 a role for G3BP1 and G3BP2 in virus replication 2 3 Ileana M. Cristea, Heather Rozjabek, Kelly R. Molloy, Sophiya Karki, Laura L. 4 White, Charles M. Rice, Michael P. Rout, Brian T. Chait and Margaret R. 5 MacDonald 6 7 Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, 8 Washington Road,...

Host factors associated with the Sindbis virus RNA - dependent RNA polymerase : 1 a role for G 3 BP 1 and G 3 BP 2 in virus replication 2 3

Different types of nsP3-containing protein complexes in Sindbis virus-infected cells.

Alphaviruses represent a serious public health threat and cause a wide variety of diseases, ranging from severe encephalitis, which can result in death or neurological sequelae, to mild infection, characterized by fever, skin rashes, and arthritis. In the infected cells, alphaviruses express only four nonstructural proteins, which function in the synthesis of virus-specific RNAs and in modifica...

Construction of a Minigenome Rescue System for Measles Virus, AIK-c Strain

Background:In the recent decade, the reverse genetics method has been broadly used for rescue of negative-stranded RNA viruses from cDNA or viral minigenomes. This technique has been applied to study different steps in virus replication and virus-host interactions. Reverse genetics could also be implemented for design of new vaccines. The T7 RNA polymerase activity as well as virus (nucleocapsi...

The Ninth Biennial All-iowa Virology Symposium

1. Stress Granule Modulation by Mammalian Orthoreovirus Factories Promisree Choudhury and Cathy L. Miller Department of Veterinary Microbiology and Preventive Medicine, Iowa State University Phosphorylation of eIF2α induces formation of discrete cytoplasmic inclusions called stress granules (SG). SGs are comprised of translationaly silenced mRNAs, translation initiation factors, ribosomal prote...